Introduction . Psilocybin (Fig.? 1 ) is the principal natural product of a polyphyletic group of fungi colloquially referred to as magic mushooms1 , 2 , 3. The phosphorylated indolethylamine is a chemically stable precursor of the psychotropic substance psilocin, which acts as a partial agonist of human 5-hydroxytryptamine (5-HT) receptors4 , 5 , 6. Therapeutic evaluation of psilocybin has revealed a remarkable capacity to alleviate a variety of psychological condit...